RG3039 0081 15 nM in EGFR Del

15 nM in EGFR Del E746_A750 containing PC9 cells

Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles

Smiles: COC1=CC=CC2C=C(NC=21)C1N=C([C@@H]2CC[C@H](CC2)C(O)=O)N2N=CN=C(N)C2=1

Stensbøl TB

DMH-1 effectively inhibits the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM)

RG3039 0081 15 nM in EGFR DelRG3039 (PF 06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4. 2 nM and IC90 of 40 nM, respectively. Product information CAS Number: 1005504 62 0 Molecular Weight: 432. 35 Formula: C21H23Cl2N5O Synonym: PF 06687859 Chemical Name: 5 ((1 (2,6 dichlorobenzyl)piperidin 4 yl)methoxy)quinazoline 2,4 diamine Smiles: